As long as the weather conditions are good and the truck has no mechanical problems, thesse things should work pretty well, Highway driving between production facilities and distribution centers is generally pretty predictable and easy. However, what happens if there is a problem like a road closure and the cops need to reroute the traffic. How do they tell the truck it needs to get off the highway and take an alternate route? If a tire has a blowout, does the truck change the tire itself? Can it call a tow service nearby? Who pumps the diesel to fill the tanks if the route is longer than a tankful?
Will there be unhappy Luddite truckers who sabotage the robotrucks?
On dedicated routes these things should more or less work. For the meat and potatoes of LTL trucking, fuhgettabouddit. Too many variables.
https://newatlas.com/automotive/aurora-driverless-trucks-texas/
Driverless freight trucks begin barreling through Texas
RE